One of the Premier League’s fiercest rivalries takes centre stage this weekend as Manchester United host Arsenal at Old Trafford with confidence dwindling for both sides.

Second-placed Aberdeen need a result against fifth-placed St. Johnstone if they are to maintain any pressure on SPL leaders Celtic.

Hearts are looking to bounce back from a defeat at basement side Dundee United when they host struggling Kilmarnock at Tynecastle on Saturday.

After being held to a draw at La Rosaleda last weekend, will Real Madrid be able to return to winning ways when they host their neighbours and rivals of Atlético next weekend at Santiago Bernabéu?

Two German heavyweights go head-to-head on Saturday afternoon as Bayern Munich look to build on their draw against Juventus midweek with victory at the Volkswagen Arena against Wolfsburg.

After three consecutive defeats, will Manchester City be able to return to winning ways when they visit Kiev next Wednesday night?

After last weekend’s compromising draw at Bologna, will Juventus be able to overcome the powerful Bayern Munich when both sides measure forces at Turin next Tuesday?

After a narrow 1-0 win against Getafe last time out, will Atlético Madrid be able to claw the three points once again in their difficult clash against Villarreal next Sunday?

After last round’s vital win over Espanyol at Mestalla, will Valencia be able to claw the three points during their predictably complicated visit to Granada?

Bayer Leverkusen play host to Borussia Dortmund with the two likely to be fighting for who finishes runners up to Bayern Munich in the Bundesliga this Sunday.